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Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. Statistical analyses were performed using the Statistical Package of Social Studies (SPSS) version 17.0 (SPSS, Inc., Chicago, IL) and SAS software version 9.4 (SAS Inc, NC, USA) for Windows. All funding for this site is provided directly by ESMO. All women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with carboplatin alone or a carboplatin-based combination chemotherapy regimen at a single hospital between January 2006 and December 2013 were retrospectively recruited. Please enable it to take advantage of the complete set of features! 10.1016/annonc/annonc687, Anaphylaxis and hypersensitivity in trials of intravenous pertuzumab + trastuzumab (PH IV) or the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection (PH FDC SC) for HER2-positive breast cancer (BC), Targeted Therapies and Precision Oncology, Interpreting Oncological Study Publications, Cancer Diagnosis and Treatment Evaluation, Cancer Treatment in Special Clinical Situations, Clinical Pharmacology of Anti-Cancer Agents, Controversies in upper GI oncology: ESMO Open Podcasts, International Prognostic Index Tools for Lymphoma, Anti-Cancer Agents and Biological Therapy, Drug-Drug Interactions with Kinase Inhibitors, PARP inhibition and DNA Damage Response (DDR), Cancer Aetiology, Epidemiology and Prevention, Cancer in Special situations (pregnancy, young, elderly, hereditary), Multikinase Inhibitor-Related Skin Toxicity, Precision Medicine and Validated Biomarkers, ESMO Recommendations in Precision Medicine. doi: 10.1006/gyno.1994.1098, Keywords: ovarian cancer, chemotherapy, carboplatin, hypersensitivity, risk factor, Citation: Tai Y-H, Tai Y-J, Hsu H-C, Lee S-P, Chen Y-Y, Chiang Y-C, Chen Y-L, Chen C-A and Cheng W-F (2017) Risk Factors of Hypersensitivity to Carboplatin in Patients with Gynecologic Malignancies. Clin Rev Allergy Immunol. Necessary cookies enable core functionality. Most IRs are mild with symptoms such as chills, fever, nausea, headache, skin rash, pruritus, etc. Utilizing Biologics in Drug Desensitization. Carriers of BRCA genes develop drug allergy after fewer exposures and can present with severe reactions, including anaphylaxis. The site is secure. A history of drug or food allergy, the presence of malignant ascites, and the cumulative carboplatin dose are three independent predictive factors of carboplatin hypersensitivity in this survey. doi: 10.1093/annonc/mdx216. Table 6. S.M. Necessary cookies enable core functionality. A framework to rank genomic alterations as targets for cancer precision medicine.ESCAT scores for genomic alterations with actionable drug matches are now being gradually integrated into ESMO tumour-focused Clinical Practice Guidelines. Clinical analysis of thirteen cases of hypersensitivity reactions to carboplatin. Bayer to Highlight New Research at ESMO 2017 Congress HHS Vulnerability Disclosure, Help Furthermore, patients with carboplatin hypersensitivity had a higher incidence of previous allergic history to other cytotoxic drugs, including gemcitabine, paclitaxel, and doxorubicin, compared to those without (12/75 vs. 30/660, P < 0.001, chi-squared test; Table 7). desensitization; drug allergy; monoclonal antibodies in cancer; platins; taxanes. One-fifth of these patients never attempt carboplatin reinfusion, even after only mild hypersensitivity reactions (Gadducci et al., 2008). Enhancing the feasibility of outpatient daratumumab administration via a split-dosing strategy with initial doses. TABLE 3 Table 3. Risk factors for these reactions included advanced disease, serous histological type, malignant ascites, and history of drug allergies. 329 (152 CPI-treated v 177 CPI-nave, including 60 tx-nave) pts with RET fusion+ NSCLC were analyzed. Zweizig, S., Roman, L. D., and Muderspach, L. I. (2015). ESMO is a Swiss-registered not-for-profit organisation. 57 . Galateanu B, Pucau AI, Tircol SA, Tanase BC, Hudita A, Negrei C, Burcea-Dragomiroiu GT, Negreanu L, Vacaroiu IA, Ginghin O. Int J Mol Sci. A cumulative search for anaphylaxis/hypersensitivity (Roche Standard Adverse Event Group Terms) across all pivotal trials cited in the current EMA P IV/PH FDC SC SmPCs. This patient developed hypersensitivity reactions during her 23rd cycle of carboplatin administration at a cumulative dose of approximately 14,000 mg. She experienced skin rash, tachycardia, and dyspnea 13 min after starting the infusion. ESMO is a Swiss-registered not-for-profit organisation. Interactive/Pocket Guideline Interactive/Pocket Guideline Constipation in Advanced Cancer 1 2 3 Management of infusion reactions to systemic anticancer therapy: ESMO Haanen JBAG, Carbonnel F, Robert C, Kerr KM, Peters S, Larkin J, Jordan K; ESMO Guidelines Committee. Management of toxicities from immunotherapy: ESMO Clinical Practice One patient who experienced a carboplatin-related hypersensitivity reaction progressed to respiratory arrest and died. News, highlights and insights download your copy here. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. These patients were provided with intravenous fluid infusion and medications, including corticosteroids, antihistamines, and oxygen application. Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions. Among 735 eligible women, 75 (10.2%) experienced a total of 215 carboplatin-related hypersensitivity reaction events. Previous data indicated that prior carboplatin exposure is the primary risk factor for carboplatin-related hypersensitivity reactions among all patients (Navo et al., 2006; Koshiba et al., 2009). Rosell S, Blasco I, Garca Fabregat L, Cervantes A, Jordan K; ESMO Guidelines Committee. ESMO on Anemia, Iron Deficiency in Cancer Patients 84, 378382. Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. 2017 Jul 1;28(suppl_4):iv119-iv142. Oncol Res Treat. Oncol. National Library of Medicine official website and that any information you provide is encrypted The ESMO 2017 Congress, in partnership with the European Association for Cancer Research (EACR), created an environment where cancer researchers and clinicians came together to collaborate and exchange ideas. Int. Met Based Drugs (2010) 2010 Available from: Markman M. Toxicities of the platinum antineoplastic agents. (Markman, 2007) reported that carboplatin-related hypersensitivity reactions rarely occur before cycle 6 or <3,000 mg of drug delivery, with the first episode most commonly occurring with carboplatin administration in the second-line setting, and carboplatin administration beyond 9 cycles or 6,000 mg increasing the risk of severe hypersensitivity reactions, similar to our present observations. These risk factors can help identify patients at greater risk of developing hypersensitivity. The rate of hypersensitivity was significantly higher among patients with advanced stage disease (IIIIV) compared to patients with early stage disease (III) (P < 0.001, Kruskal-Wallis test), and among patients with serous or mixed histological type compared to patients with other histological types (P = 0.003, Kruskal-Wallis test). Monitor. Author Information. J. Clin. 2022 Jun 16;3:868300. doi: 10.3389/falgy.2022.868300. Abe, A., Ikawa, H., and Ikawa, S. (2010). Federal government websites often end in .gov or .mil. Gynecol. All funding for this site is provided directly by ESMO. Lacouture, V. Sibaud, P.A. Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. Gerber, C. van den Hurk, P. Fernndez-Peas, D. Santini, F. Jahn, K. Jordan on behalf of the ESMO Guidelines Committee These ESMO Clinical Practice Guidelines provide recommendations on the . Expert Perspectives: ESMO 2017 Changes Lung Cancer Practice Int. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. Parmar et al. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. MBC: CLEOPATRA (NCT00567190; PMID 22149875, 23602601, 25693012; 32171426), MetaPHER (NCT02402712; 33748921); EBC: APHINITY (NCT01358877; 28581356, 33539215), NeoSphere (NCT00545688; 22153890, 27179402), TRYPHAENA (NCT00976989; 23704196, 29223479), BERENICE (NCT02132949; 29253081, SABCS 2017 P5-20-04), FeDeriCa (NCT03493854; 33357420), PHranceSCa (NCT03674112; ESMO 2020 165MO). In the US, PH FDC SC can be administered by healthcare professionals in patients (pts) homes. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. Therefore, disease severity, histological type, malignant ascites, past drug allergies, and cumulative carboplatin dose are risk factors for carboplatin-related hypersensitivity reactions. Carboplatin hypersensitivity: evaluation and successful desensitization protocol. Bethesda, MD 20894, Web Policies ESMO Virtual Congress 2020 | OncologyPRO LUGANO-MADRID, 09 September, 2017 -The preliminary results of a study to be presented at the ESMO 2017 Congress in Madrid (1) show that socio-psychological factors have become more significant for . Epub 2011 Jan 26. In our study, 36% of the patients with carboplatin-related hypersensitivity reactions had a history of drug allergies. Cancer. Monitor. Chemother. We retrieved clinical information, including age, menopausal status, cancer stage, surgical findings, chemotherapeutic treatment history, recurrence status, and survivorship, from the clinical and operative notes and discharge summaries stored in a centralized database. Hypersensitivity to antineoplastic agents. J. Gynecol. In the present study, 61 patients with carboplatin-related hypersensitivity were rechallenged with carboplatin. Pegylated liposomal doxorubicin and carboplatin compared with paclitaxel and carboplatin for patients with platinum-sensitive ovarian cancer in late relapse. Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies. Oncol. J Oncol Pract. de Las Vecillas Snchez L, Alenazy LA, Garcia-Neuer M, Castells MC. Ke. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. 17 This dose reduction is due to the ability of both aprepitant and netupitant to inhibit the metabolism of dexamethasone leading to higher . Management of infusion reactions to systemic anticancer therapy: ESMO 2012;97:217-33. doi: 10.1159/000335637. Our present findings confirmed these factors and identified other risk factors, including advanced disease, serous histology, and the presence of malignant ascites. Authors S Rosell 1 , I Blasco 1 , L Garca Fabregat 1 , A Cervantes 1 , K Jordan 2 ; ESMO Guidelines Committee -, A fatal anaphylactic reaction to paclitaxel is described, which was preceded by a possible delayed reaction to the initial infusion. The ESMOClinical Practice Guidelines(CPGs) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings ofevidence-based medicine. doi: 10.1006/gyno.2001.6519, Gadducci, A., Tana, R., Teti, G., Zanca, G., Fanucchi, A., and Genazzani, A. R. (2008). Atopic patients are at increased risk for chemotherapy and MoAbs drug allergy and the current patterns of treatment with recurrent and intermittent drug exposures may favor the development of drug allergies. (2003). Immunotherapy 6, 905912. Za. Carboplatin induces DNA double strand breaks, which are repaired by BRCA recombination repair enzymes. Rapid drug desensitization for hypersensitivity reactions to chemotherapy and monoclonal antibodies in the 21st century. Supportive. See this image and copyright information in PMC. Abe et al. Epub 2019 Mar 8. (2003) reported that paclitaxel with platinum improves overall survival compared to conventional platinum-based chemotherapy among patients with relapsed platinum-sensitive ovarian cancer. A video magazine about the congress, highlighting the most important information about the event. 8600 Rockville Pike Necessary cookies enable core functionality. Only 2 women are Mongolians and the other 733 women are Asian Taiwanese. doi: 10.1016/S0140-6736(03)13718-X, Pfisterer, J., Plante, M., Vergote, I., du Bois, A., Hirte, H., Lacave, A. J., et al. Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Gynecol. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23. Bookshelf Do Steroids Matter? A Retrospective Review of Premedication for Taxane Careers. sharing sensitive information, make sure youre on a federal 66, 730. Arnall JR, Moore DC, Hill HL, Griffin S, Mueller MK, Lavery LA, Voorhees PM, Usmani SZ. J. Clin. Women are more affected by drug allergy and up to 27% of women with ovarian and breast cancer develop carboplatin allergy after multiple cycles of treatment. J. Clin. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23. Overall, the evidence supports that the number of carboplatin cycles and dose are the principal risk factors for carboplatin-related hypersensitivity reactions, and that caution is warranted in cases of carboplatin infusion beyond 8 cycles or 3,500 mg. Anaphylaxis and hypersensitivity in trials of intravenous pertuzumab Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). ESMO 2017 Congress | Madrid, Spain | Oncology Conferences Same-Day Desensitization in Patients Who Experience Their First Reaction to a Platin Agent at the Oncology Day Unit: A Pilot Study to Safely Include This Technique Within the Multidisciplinary Pathways for the Diagnosis & Management of Hypersensitivity to Platin Agents. The dilemma of carboplatin-associated hypersensitivity reactions in ovarian cancer management. Multivariate analyses of clinical parameters for carboplatin-related hypersensitivity reactions. . 2017 Nov 8;8:1472. doi: 10.3389/fimmu.2017.01472. Published in 2020 - Ann Oncol (2020) Authors: M.E. Tx-nave pts ORR was 90%. Patients with prior drug or food allergies should be closely monitored during carboplatin administration. Read guidelines by topic Latest Guidelines News Algorithm for the evaluation of drug hypersensitivity reactions and the role of desensitization for the re-introduction of the first-line medications, when no alternative is available or the alternative does not provide the same benefits or life expectancy as the first line. Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report. Epub 2022 Nov 29. This exciting partnership delivered a unique cancer congress in Europe with huge scientific reach and the true potential to improve the lives of cancer patients. Invest. Study conception and design: Y-HT and W-FC. 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Disclaimer. 66, 265267. Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: An intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG. Table 4. doi: 10.1002/pbc.25697, Siegel, R. L., Miller, K. D., and Jemal, A. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. Carboplatin-related hypersensitivity reactions sometimes result in premature discontinuation of treatment (Schwartz et al., 2007). http://downloads.hindawi.com/journals/mbd/2010/207084.pdf, Kadoyama K, Kuwahara A, Yamamori M, Brown JB, Sakaeda T, Okuno Y. Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS. Adnan A, Acharya S, Alenazy LA, de Las Vecillas L, Giavina Bianchi P, Picard M, Calbache-Gil L, Romero-Pinedo S, Abad A-Molina AC, Kerr W, Pedicone C, Nagai J, Hollers E, Dwyer D, Castells M. J Immunol.

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